Contraindicated (one)pentobarbital will lower the level or impact of cariprazine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is responsible for the development and elimination of cariprazine's Lively metabolites.
pentobarbital will lower the extent or impact of mifepristone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. CYP3A4 inducers haven't been examined, coadministration not suggested by manufacturer
Reserve concomitant prescribing of those medicines in sufferers for whom other cure selections are inadequate. Limit dosages and durations towards the least expected. Keep an eye on carefully for indications of respiratory despair and sedation.
pentobarbital will lower the extent or outcome of midazolam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will lower the extent or effect of voriconazole by impacting hepatic enzyme CYP2C9/ten metabolism. Insignificant/Importance Unknown.
Keep track of Intently (two)pentobarbital will lower the level or effect of suvorexant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Powerful CYP3A4 inducers may perhaps lessen suvorexant efficacy; if enhanced suvorexant dose demanded, will not exceed twenty mg/day
Watch Carefully (1)pentobarbital will reduce the level or effect of exemestane by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. For people acquiring exemestane which has a strong CYP3A4 inducer the recommended dose of exemestane is 50 mg day by day following a food.
pentobarbital increases effects of ifosfamide by impacting hepatic enzyme CYP2B6 metabolism. Use Caution/Keep an eye on. Coadministration of ifosfamide with CYP2B6 inducers may well improve metabolism of ifosfamide to its metabolite. Watch for elevated results/toxicities if coupled with CYP2B6 inducers.
benzhydrocodone/acetaminophen and pentobarbital here both equally increase sedation. Stay clear of or Use Alternate Drug. Limit use to clients for whom different procedure alternatives are insufficient
Check Carefully (1)pentobarbital will increase the amount or influence of clopidogrel by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will reduce the level or outcome of lonafarnib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib can be a sensitive CYP3A4 substrate. Coadministration with strong or average CYP3A4 inducers is contraindicated.
pentobarbital will lower the level or result of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will minimize the level or outcome of oliceridine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. If coadministration that has a CYP3A4 inducer is important, take into account expanding oliceridine dose till stable drug outcomes are obtained; keep track of for indications of opioid withdrawal.
Contraindicated (1)pentobarbital will reduce the extent or result of fostemsavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism.